heart failure — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10515	Anti-Heart Failure Agent 1		Others
	Anti-Heart Failure Agent 1 is an orally available compound suitable for the treatment of heart failure without inducing vomiting, nausea, and restlessness.		Others
T2320	Indacaterol		Adrenergic Receptor
	Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.		Adrenergic Receptor
T5033	Olprinone	Loprinone	PDE
	Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output ...		PDE
T9022	AZD9977	AZD 9977	Glucocorticoid Receptor
	AZD9977 is a novel, selective modulator of mineralocorticoid receptor .		Glucocorticoid Receptor
T7686	Ramiprilat		RAAS
	Ramiprilat is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.		RAAS
T16873	SERCA2a activator 1		Calcium Channel
	SERCA2a activator 1 is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a activator. SERCA2a activator 1 decreases phospholamban inhibition and enhances the systolic and diastolic functions of the heart.		Calcium Channel
T8149	Dobutamine hydrochloride	Dobutamine (hydrochloride)	Adrenergic Receptor
	Dobutamine hydrochloride (Dobutamine (hydrochloride)) is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects.		Adrenergic Receptor
T14989	CMPD101		ROCK , GRK , PKC
	CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with I...		ROCK , GRK , PKC
T39789	BMS-986235	BMS-986235,LAR-1219	Others
	BMS-986235 (LAR-1219) is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 can be used in studies about the preventio...		Others
T6716	Valsartan	Diovan,Tareg,CGP 48933	RAAS
	Valsartan (CGP 48933) is a tetrazole derivative and angiotensin II type 1 receptor blocker that is used to treat hypertension.		RAAS
T5329	Trandolapril		Angiotensin-converting Enzyme (ACE)
	Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that is hydrolysed to the active diacid trandolaprilat.		Angiotensin-converting Enzyme (ACE)
T1461	Candesartan	CV 11974	RAAS
	Candesartan (CV 11974) is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure.		RAAS
T4574	Sacubitril	AHU 377,AHU377,AHU-377	Neprilysin
	Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696.		Neprilysin
T1410	Torsemide	AC-4464,JDL-464,Torasemide	Na-K-Cl cotransporter
	Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and h...		Na-K-Cl cotransporter
T7714	Temocapil		Tyrosinase
	Temocapril is an inhibitor of tyrosine kinase.		Tyrosinase
T8183	Deslanoside	Desacetyllanatoside C,Deacetyllanatoside C	ATPase , Drug Metabolite
	Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms. Deslanoside inhibits the Na-K-ATPase membrane p...		ATPase , Drug Metabolite
T3465	Vesnarinone	OPC-8212,Arkin,Piteranometozine	HIV Protease , PDE
	Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cel...		HIV Protease , PDE
T24850	Takeda103A	CMPD103A,Takeda-103A,Takeda-103-A,CMPD-103A,Takeda 103 A	GRK
	Takeda103A (CMPD103A) is the GRK2-dependent bovine tubulin oxidation effective inhibitor.		GRK
T1239	Indacaterol maleate	QAB149	Adrenergic Receptor
	Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.		Adrenergic Receptor
T0154	Nebivolol hydrochloride	R 065824 hydrochloride,Nebivolol HCl,R-65824	Apoptosis , Adrenergic Receptor
	Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is us...		Apoptosis , Adrenergic Receptor